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Vitbion Forte


DESCRIPTION
TABLET
Colour : Orange
Shape : Round a Biconvex
Coating : Film-coated

CONTENT
Each tablet contain:

Thiamine HCI .............................. 100 mg
Pyridoxine HCI ............................ 200 mg
Cyanocobalamin .......................... 200 g

PHARMACODYNAMICS
Thiamine is fundamentally associated with carbohydrate metabolism. By combining with the pyrophosphoric acid in nucleated cells, particularly in the liver, kidneys, and white blood cells, it is converted in the body to its pyrophosphate (cocarboxylase) which acts as a coenzyme in such reactions as the decarboxylation of alpha-keto acids, particularly of pyruvate and alpha-ketoglutarate. In the presence of thiamine deficiency pyruvic and lactic acids accumulate in the tissues. Thiamine pyrophosphate also acts as a coenzyme in the direct oxidative pathway of glucose metabolism.

 

Pyridoxine is converted to pyridoxal phosphate, which is the coenzyme for a variety of metabolic functions affecting protein, carbohydrate and lipid utilization. Pyridoxine is involved in conversion of tryptophan to niacin or serotonin.

 

Cyanocobalamin is a member of a group of similar compounds, which influence erythropoiesis. It is used in the treatment of pernicious anaemia and its neurological complication. It is also used in the treatment of other macrocytic anaemias associated with nutritional deficiencies.

PHARMACOKINETICS
Thiamine is absorbed from the GIT and is widely distributed to most body tissues. It is not stored to any appreciable extent in the body and amounts in excess of the body's requirements are excreted in the urine as unchanged thiamine or as metabolites. About 1 mg of thiamine is metabolised in the body daily. Pyridoxine is converted to the active form pyridoxal phosphate. Pyridoxal and pyridoxamine are also absorbed and converted. It is excreted in the urine as 4-pyridoxic acid.


Large doses of cyanocobalamin are irregularly absorbed after oral administration is impaired when intrinsic factor is deficient or when gastrointestinal disease is present. It is stored in the liver, undergoes enterohepatic circulation, and crosses the placenta. 50% of a dose is excreted in the urine in 48 hours along with significant amounts in bile.

INDICATIONS
It is used as a supplement in the treatment of polyneuritis, neuralgias, diabetic neuropathy, drug-induced neuropathy.

RECOMMENDED DOSAGE
For therapeutic use: 1 tablet 3 times daily.

SIDE EFFECTS/ADVERSE REACTIONS
Vitamin B groups are water-soluble vitamins and they do not cause any side effects if taken accordingly to the recommended dosage.

SYMPTOMS AND TREATMENT OF OVERDOSE
Overdosage rarely occur.

Excess Vitamin B will be excreted in the urine.

PACKING/PACK SIZES
Plastic container of 60's.
Plastic containers of 180's and 1000's (For EXPORT/TENDER Only).

Blister pack of 3 x 12's, 10 x 10's and 100 x 10's per box.

SHELF LIFE
4 years from the date of manufacture.

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