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Zoral cream

COMPOSITION
Acyclovir USP 5% w/w

PRESERVATIVE
Methyl Hydroxybenzoate BP 0.06% w/w, Propyl Hydroxybenzoate BP 0.03% w/w

PRODUCT DESCRIPTION
Non-greasy white cream.

PHARMACOLOGY
Acyclovir is active against herpes simplex virus type 1 and type 2 and against varicella zoster virus. This activity is due to intracellular conversion of acyclovir by a viral thymidine kinase to the monophosphate with subsequent conversion to the diphosphate and active triphosphate. This active form inhibits the herpes virus DNA polymerise enzyme as well as being incorporated into viral DNA. This process is highly selective for infected cells. Studies in animals and in vitro show various sensitivities but demonstrate that these viruses are inhibited by concentrations of acyclovir that are readily achieved clinically. Herpes simplex virus type 1 appear to be the most susceptible, than type 2, followed by varicella zoster virus.

INDICATIONS
Herpes simplex virus infections of the skin including initial and recurrent genital herpes and herpes labialis.

ADMINISTRATION
Apply to lesions or impending lesions 5 times daily at 4-hourly intervals omitting the night-time dose. Treatment should start as early as possible after the start of an infection. For recurrent episodes, it is important to start treatment during the prodromal period or when the lesions first appear. Continue treatment for 5 days. Treatment may be continued for up to 10 days if healing has not occurred.

ADVERSE EFFECT
Transient burning or stinging, mild drying and flaking of skin, erythema and itching.

PRECAUTION
Not to be applied to mucous membranes, such as mouth, eye or vagina.

USE IN PREGNANCY
Should be used only if potential benefits outweigh the risks.

CONTRA-INDICATIONS
Contraindicated in patients known to be hypersensitive to acyclovir.

DRUG INTERACTIONS
There is no reported drug interaction with topical acyclovir. Drug affecting renal physiology could influence the pharmacokinetics of systemically administered acyclovir.

PACKING

2g & l0g in aluminium tube


STORAGE

Store below 25C

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